Death Drain is a power-up at the end of a guitar battle if no player is eliminated. It's the only power-up you can get when you're in Sudden Death. This feature was added in Guitar Hero III and Aerosmith as the battles were also featured in those games. In the boss battles, you always lose at the end of the song because only the boss can get the Death Drain.
- Three and Aerosmith were the only games to have this power-up.
- Online lag can cause the Death Drain power-up to not end a battle as seen in this video.